Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone.

@article{Wong2000PronouncedAS,
  title={Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone.},
  author={M L Wong and Mitchel A. Kling and Peter J. Munson and Samuel J Listwak and Julio Licinio and Paolo Prolo and Brian J Karp and Ian E. Mccutcheon and Thomas D. Geracioti and Michael DeBellis and Kenner C. Rice and David S Goldstein and Johannes D. Veldhuis and George P. Chrousos and Edward Hudson Oldfield and S M Mccann and Philip W. Gold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 1},
  pages={325-30}
}
Both stress-system activation and melancholic depression are characterized by fear, constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine function. Because norepinephrine (NE) and corticotropin-releasing hormone (CRH) can produce these physiological and behavioral changes, we measured the cerebrospinal fluid (CSF) levels each hour for 30 consecutive hours in controls and in patients with melancholic depression. Plasma adrenocorticotropic hormone (ACTH… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
196 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 196 extracted citations

References

Publications referenced by this paper.

Neurobiology of Mood Disorders (Williams and Wilkins, Baltimore)

  • R. M. Post, J. C. Ballenger
  • 1984

Similar Papers

Loading similar papers…