Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge.

  title={Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge.},
  author={Sandra S. Cohen and C Li and Lina Ding and Yuan Cao and Arthur B. Pardee and Ethan M Shevach and David I. Cohen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 19},
HIV infection is accompanied by an early immune dysfunction limiting host control of virus and likely contributing to difficulties in achieving a successful vaccine against HIV. We report here that the HIV Tat protein is strongly immunosuppressive, both immediately after immunization of mice with soluble protein (sTat), and in seroconverting humans, and propose that Tat-induced suppression cripples immune surveillance to HIV infection. We show that macrophages are sensitive to sTat stimulation… CONTINUE READING