Proneurotrophins, seizures, and neuronal apoptosis.

  title={Proneurotrophins, seizures, and neuronal apoptosis.},
  author={Wilma J Friedman},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={16 3},
Neurons respond to numerous factors in their environment that influence their survival and function during development and in the mature brain. Among these factors, the neurotrophins have been shown to support neuronal survival and function, acting primarily through the Trk family of receptor tyrosine kinases. However, recent studies have established that the uncleaved neurotrophin precursors, the proneurotrophins, can be secreted and induce apoptosis via the p75 neurotrophin receptor… CONTINUE READING
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