Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.

@article{Castro2006ProneuralBA,
  title={Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.},
  author={Diogo S Castro and Dorota Skowronska-Krawczyk and Olivier Armant and Ian John Donaldson and Carlos M. Parras and Charles Hunt and James A Critchley and Laurent Nguyen and Achim Gossler and Berthold G{\"o}ttgens and Jean-Marc Matter and François Guillemot},
  journal={Developmental cell},
  year={2006},
  volume={11 6},
  pages={
          831-44
        }
}
Proneural proteins play a central role in vertebrate neurogenesis, but little is known of the genes that they regulate and of the factors that interact with proneural proteins to activate a neurogenic program. Here, we demonstrate that the proneural protein Mash1 and the POU proteins Brn1 and Brn2 interact on the promoter of the Notch ligand Delta1 and synergistically activate Delta1 transcription, a key step in neurogenesis. Overexpression experiments in vivo indicate that Brn2, like Mash1… CONTINUE READING
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