Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury.

@article{Santana2009PronePP,
  title={Prone position prevents regional alveolar hyperinflation and mechanical stress and strain in mild experimental acute lung injury.},
  author={Maria Cristina Ebole Santana and Cristiane Souza Nascimento Baez Garcia and D{\'e}bora Gonçalves Xisto and Lilian Kati{\^e} da Silva Nagato and Roberta M Lassance and Luiz Felipe Mancilha Prota and Felipe Mateus Ornellas and Vera L{\'u}cia Capelozzi and Marcelo Marcos Morales and Walter Ara{\'u}jo Zin and Paolo Pelosi and Patricia R M Rocco},
  journal={Respiratory physiology & neurobiology},
  year={2009},
  volume={167 2},
  pages={181-8}
}
Prone position may delay the development of ventilator-induced lung injury (VILI), but the mechanisms require better elucidation. In experimental mild acute lung injury (ALI), arterial oxygen partial pressure (Pa O2), lung mechanics and histology, inflammatory markers [interleukin (IL)-6 and IL-1 beta], and type III procollagen (PCIII) mRNA expressions were analysed in supine and prone position. Wistar rats were randomly divided into two groups. In controls, saline was intraperitoneally… CONTINUE READING
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