Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression

@inproceedings{Chen2015PromyelocyticLP,
  title={Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression},
  author={Yixiang Chen and Jordan Wright and Xueqiong Meng and Keith N Leppard},
  booktitle={Molecular and cellular biology},
  year={2015}
}
To trigger type I interferon (IFN) responses, pattern recognition receptors activate signaling cascades that lead to transcription of IFN and IFN-stimulated genes (ISGs). The promyelocytic leukemia (PML) protein has been implicated in these responses, although its role has not been defined. Here, we show that PML isoform II (PML-II) is specifically required for efficient induction of IFN-β transcription and of numerous ISGs, acting at the point of transcriptional complex assembly on target gene… CONTINUE READING
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References

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SHOWING 1-10 OF 103 REFERENCES

Identification of novel alternative splicing variants of interferon regulatory factor 3.

  • Biochimica et biophysica acta
  • 2011
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Pathogen recognition and inflammatory signaling in innate immune defenses.

  • Clinical microbiology reviews
  • 2009
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL