Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.

  title={Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.},
  author={Edgardo J. Arroyo and John R. Bermingham and Michael G. Rosenfeld and Steven S. Scherer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 19},
Tst-1/SCIP/Oct-6, a POU domain transcription factor, is transiently expressed by developing Schwann cells and is required for their normal development into a myelinating phenotype. In tst-1/scip/oct-6-null sciatic nerves, Schwann cells are transiently arrested at the "promyelinating" stage, when they have a one-to-one relationship with an axon but before they have elaborated a myelin sheath. To determine when Schwann cells express Tst-1/SCIP/Oct-6, we examined beta-galactosidase (beta-gal… CONTINUE READING