Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni.

@article{Badawi1993PromutagenicMD,
  title={Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni.},
  author={Alaa Badawi and D. P. Cooper and Mostafa Mostafa and Michael J. Doenhoff and A. J. Probert and Padraic Fallon and Ryan A. Cooper and Peter J. O'Connor},
  journal={Carcinogenesis},
  year={1993},
  volume={14 4},
  pages={653-7}
}
Male and female BK-TO mice were infected with different numbers of Schistosoma mansoni cercariae under standard environmental conditions. Promutagenic methylation damage (O6-methyldeoxyguanosine; O6-MedG) was detected in liver DNA, but not in kidney, spleen or bladder DNA of infected animals. It was shown that levels of hepatic O6-MedG increased with increasing intensities of schistosomal infection. Possible mechanisms of action are discussed. These include the activating effects of… CONTINUE READING

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