Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice

@article{Aldhalimi2014PromotiveEO,
  title={Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice},
  author={Muhsin A. Aldhalimi and Najah Hadi and Fadaa A. Ghafil},
  journal={ISRN Pharmacology},
  year={2014},
  volume={2014}
}
Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. [] Key Method Coat hairs on the dorsal skin of seven weeks old male mice were gently clipped and then stained by using commercial dye. These mice were divided into four groups each of five treated with topical application of ethanol 95%, Ketoconazole solution 2%, Minoxidil solution 5%, and Minoxidil with Tretinoin solution 0.1%, respectively.

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References

SHOWING 1-10 OF 52 REFERENCES

Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice

The results suggest that topical applications of the substance are useful for treating seborrheic dermatitis accompanied by hair regression or male pattern hair loss.

Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution

Percutaneous minoxidil absorption is enhanced by tretinoin as a result of increased stratum corneum permeability, and transepidermal water loss measurements, which are sensitive to changes in stratum Corneum function, were significantly increased with t retinoin.

Promotive Effect of Minoxidil Combined with All-trans Retinoic Acid (tretinoin) on Human Hair Growth in Vitro

The results suggest that minoxidil plus ATRA would additively enhance hair growth by mediating dual functions: the prolongation of cell survival by activating the Erk and Akt signaling pathways, and the prevention of apoptosis of DPCs and epithelial cells by increasing the ratio of Bcl-2/Bax and downregulating the expressions of P53 and P21.

Topical tretinoin for hair growth promotion.

Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity.

Topical minoxidil in early male pattern baldness.

Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp.

Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men.

Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men

It is inferred that the therapeutic efficacy is enhanced by combining the two drugs acting on different aetiological aspects of AGA by combining finasteride alone or in combination with minoxidil or ketoconazole.

Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA

Aggressively treating AGA achieves significant and rapid growth of new hair in atopic and nonatopic male patients, with attention to male patients who are atopic.
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