Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice

  title={Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice},
  author={Muhsin A. Aldhalimi and Najah Hadi and Fadaa A. Ghafil},
  journal={ISRN Pharmacology},
Recently topical use of 2% Ketoconazole solution has been reported to have a therapeutic effect on androgenic alopecia. [] Key Method Coat hairs on the dorsal skin of seven weeks old male mice were gently clipped and then stained by using commercial dye. These mice were divided into four groups each of five treated with topical application of ethanol 95%, Ketoconazole solution 2%, Minoxidil solution 5%, and Minoxidil with Tretinoin solution 0.1%, respectively.

Trichogenic effect of topical ketoconazole versus minoxidil 2% in female pattern hair loss: a clinical and trichoscopic evaluation

Topical ketoconazole mediates a trichogenic effect in FPHL with few side effects, however, ketconazole showed a delayed improvement versus minoxidil at similar concentrations.


Consuming functional foods and drinks such as kombucha tea is believed to give many beneficial effects for promoting immunity and preventing cancer. This study was carried out to investigate hair

Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review

Topical ketoconazole is a promising adjunctive or alternative therapy in the treatment of AGA and demonstrated clinical improvement of AGA based on photographic assessment and subjective evaluation.

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

Oral minoxidil 5 mg once daily effectively increased hair growth in male patients with AGA and had a good safety profile in healthy subjects, however, oral minoxIDil should be used carefully with men who have severe hypertension and increased risk for cardiovascular events.

Topical ketoconazole: a systematic review of current dermatological applications and future developments

Topical KTZ is clinically effective for the treatment of Malassezia-related conditions such as seborrheic dermatitis (SD) and pityriasis versicolor (PV) with a reported efficacy of 63–90% and 71–89%, respectively.

Experimental and early investigational drugs for androgenetic alopecia

It is proposed that topically applied medications, or intra-dermal injected or implanted materials, are preferable treatment modalities, minimizing side effect risks as compared to systemically applied treatments.

Spray-Dried Rosuvastatin Nanoparticles for Promoting Hair Growth

Rosuvastatin nanoparticles prepared by nanospray drying technique could be a good competitor to minoxidil for hair growth–promoting activity.

Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice

For the first time, results suggest that MSC-EVs have a potential to activate DP cells, prolonged survival, induce growth factor activation in vitro, and promotes hair growth in vivo.



Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice

The results suggest that topical applications of the substance are useful for treating seborrheic dermatitis accompanied by hair regression or male pattern hair loss.

Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution

Percutaneous minoxidil absorption is enhanced by tretinoin as a result of increased stratum corneum permeability, and transepidermal water loss measurements, which are sensitive to changes in stratum Corneum function, were significantly increased with t retinoin.

Promotive Effect of Minoxidil Combined with All-trans Retinoic Acid (tretinoin) on Human Hair Growth in Vitro

The results suggest that minoxidil plus ATRA would additively enhance hair growth by mediating dual functions: the prolongation of cell survival by activating the Erk and Akt signaling pathways, and the prevention of apoptosis of DPCs and epithelial cells by increasing the ratio of Bcl-2/Bax and downregulating the expressions of P53 and P21.

Topical tretinoin for hair growth promotion.

Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity.

Topical minoxidil in early male pattern baldness.

Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp.

Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men.

Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men

It is inferred that the therapeutic efficacy is enhanced by combining the two drugs acting on different aetiological aspects of AGA by combining finasteride alone or in combination with minoxidil or ketoconazole.

Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA

Aggressively treating AGA achieves significant and rapid growth of new hair in atopic and nonatopic male patients, with attention to male patients who are atopic.