Promotion of sleep by targeting the orexin system in rats, dogs and humans

@article{BrisbareRoch2007PromotionOS,
  title={Promotion of sleep by targeting the orexin system in rats, dogs and humans},
  author={C. Brisbare-Roch and J. Dingemanse and R. Koberstein and P. Hoever and H. Aissaoui and Susan Flores and C. Mueller and Oliver Nayler and J. Gerven and S. Haas and P. Hess and C. Qiu and Stephan Buchmann and M. Scherz and T. Weller and W. Fischli and M. Clozel and F. Jenck},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={150-155}
}
Orexins are hypothalamic peptides that play an important role in maintaining wakefulness in mammals. Permanent deficit in orexinergic function is a pathophysiological hallmark of rodent, canine and human narcolepsy. Here we report that in rats, dogs and humans, somnolence is induced by pharmacological blockade of both orexin OX1 and OX2 receptors. When administered orally during the active period of the circadian cycle, a dual antagonist increased, in rats, electrophysiological indices of both… Expand
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