Promotion of oxidative damage to arachidonic acid and alpha 1-antiproteinase by anti-inflammatory drugs in the presence of the haem proteins myoglobin and cytochrome C.

@article{Evans1994PromotionOO,
  title={Promotion of oxidative damage to arachidonic acid and alpha 1-antiproteinase by anti-inflammatory drugs in the presence of the haem proteins myoglobin and cytochrome C.},
  author={Patricia J. Evans and Dayọ̀ {\`A}k{\`a}nm{\'u} and Barry Halliwell},
  journal={Biochemical pharmacology},
  year={1994},
  volume={48 12},
  pages={
          2173-9
        }
}
  • Patricia J. Evans, Dayọ̀ Àkànmú, Barry Halliwell
  • Published 1994
  • Chemistry, Medicine
  • Biochemical pharmacology
  • A mixture of myoglobin and hydrogen peroxide (H2O2) causes peroxidation of arachidonic acid. This peroxidation is greatly accelerated by adding phenylbutazone, which is effective even in the absence of H2O2. A wide range of other drugs was examined for their ability to exert similar pro-oxidant effects. We found that meclofenamic acid and flufenamic acid stimulated myoglobin-dependent lipid peroxidation, but only in the presence of H2O2. Ascorbic acid inhibited peroxidation both in the presence… CONTINUE READING

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