Promotion of neutrophil chemotaxis through differential regulation of beta 1 and beta 2 integrins.

@article{Harler1999PromotionON,
  title={Promotion of neutrophil chemotaxis through differential regulation of beta 1 and beta 2 integrins.},
  author={Mary Beth Harler and Eric Wakshull and Edward J. Filardo and Jorge E. Albina and Jonathan S Reichner},
  journal={Journal of immunology},
  year={1999},
  volume={162 11},
  pages={6792-9}
}
Migration of neutrophils requires sequential adhesive and deadhesive interactions between beta 1 and beta 2 integrins and components of the extracellular matrix. Prompted by reports that describe interaction of soluble beta-glucan with the beta 2 integrin Mac-1, a role for beta-glucan in regulation of integrin-mediated migration was investigated. Neutrophil migration in response to fMLP was assessed using an agarose overlay method with slides precoated with fibronectin (Fn) +/- beta-glucan. On… CONTINUE READING
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