Promotion of neutrophil apoptosis by TNF-alpha.

  title={Promotion of neutrophil apoptosis by TNF-alpha.},
  author={Gabriela Ver{\'o}nica Salamone and Mirta Nilda Giordano and Anal{\'i}a S Trevani and Romina Gamberale and M{\'o}nica Vermeulen and Jorge Schettinni and Jorge Ra{\'u}l Geffner},
  journal={Journal of immunology},
  volume={166 5},
We examined the ability of TNF-alpha to modulate human neutrophil apoptosis. Neutrophils cultured with TNF-alpha alone undergo a low but significant increase in the number of apoptotic cells. More interestingly, when neutrophils were pretreated with TNF-alpha for 1-2 min at 37 degrees C and then were exposed to a variety of agents such as immobilized IgG, IgG-coated erythrocytes, complement-treated erythrocytes, zymosan, PMA, zymosan-activated serum, fMLP, Escherichia coli, and GM-CSF for 3 h… CONTINUE READING
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