Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model.

@article{Moghaddam2009PromotionOL,
  title={Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model.},
  author={Seyed Javad Mirhassani Moghaddam and Huaiguang Li and S. Cho and Megan K. Dishop and Ignacio Wistuba and Lin Ji and Jonathan M. Kurie and Burton F Dickey and Francesco J. Demayo},
  journal={American journal of respiratory cell and molecular biology},
  year={2009},
  volume={40 4},
  pages={443-53}
}
Lung cancer is the leading cause of cancer deaths in the United States. In addition to genetic abnormalities induced by cigarette smoke, several epidemiologic studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lungs, have an increased risk of lung cancer (1.3- to 4.9-fold) compared to smokers without COPD. This suggests a link between chronic airway inflammation and lung carcinogenesis, independent of tobacco smoke exposure. We… CONTINUE READING
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