Promotion of hexagonal phase formation and lipid mixing by fatty acids with varying degrees of unsaturation.

@article{Epand1991PromotionOH,
  title={Promotion of hexagonal phase formation and lipid mixing by fatty acids with varying degrees of unsaturation.},
  author={Richard M Epand and Naveed Ahmed and Rongjia Chen},
  journal={Chemistry and physics of lipids},
  year={1991},
  volume={57 1},
  pages={75-80}
}
A series of C18 and C22 fatty acids, with varying degrees of unsaturation, were tested for their ability to alter the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine. Lowering the pH from 7.4 to 6.4 greatly decreased the bilayer to hexagonal phase transition temperature of fatty acid-phosphatidylethanolamine mixtures. At pH 7.4, increasing unsaturation of the fatty acid generally increased their hexagonal phase-forming ability. However, oleic acid had… CONTINUE READING