Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.

@article{Sanders2000PromotionOH,
  title={Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.},
  author={Sean Sanders and Snorri Thorgeirsson},
  journal={Molecular carcinogenesis},
  year={2000},
  volume={28 3},
  pages={168-73}
}
Previous work has shown that phenobarbital (PB) can promote cell survival in double transgenic c-myc/transforming growth factor (TGF)-alpha mice. This was achieved through a suppression of cell death brought about, at least in part, by a general increase in the level of bcl-2 protein and a decrease in TGF-beta1 in treated versus untreated animals. No changes were found in TGF-beta type II receptor or in bcl-X(L) protein levels. In the present work, we followed these animals for up to 31 wk of… CONTINUE READING