Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity.

@article{Hack1993PromotionOG,
  title={Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity.},
  author={Nicolas Hack and Hiroyoshi Hidaka and Matthew J. Wakefield and R{\'o}bert Bal{\'a}zs},
  journal={Neuroscience},
  year={1993},
  volume={57 1},
  pages={9-20}
}
Cerebellar granule cells in culture develop survival requirements which can be met either by chronic membrane depolarization (25 mM K+) or by stimulation of ionotropic excitatory amino acid receptors. We observed previously that this trophic effect is mediated via Ca2+ influx, either through dihydropyridine-sensitive, voltage-dependent calcium channels (activated directly by high K+ or indirectly by kainate) or through N-methyl-D-aspartate receptor-linked ion channels. Steps after Ca2+ entry in… CONTINUE READING
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