Promotion of endometriosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats and mice: time-dose dependence and species comparison.

@article{Cummings1996PromotionOE,
  title={Promotion of endometriosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats and mice: time-dose dependence and species comparison.},
  author={A. Cummings and J. L. Metcalf and L. Birnbaum},
  journal={Toxicology and applied pharmacology},
  year={1996},
  volume={138 1},
  pages={
          131-9
        }
}
  • A. Cummings, J. L. Metcalf, L. Birnbaum
  • Published 1996
  • Medicine
  • Toxicology and applied pharmacology
  • In the disease of endometriosis, endometrial tissue grows outside the uterus, usually in the peritoneal cavity. Rodent models of endometriosis allow a way to reproduce the disease, evaluate effects of chemicals, and study mechanisms. Twenty-one days prior to induction surgery which produces endometriosis, female Sprague-Dawley rats and B6C3F1 mice were pretreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 0, 3 or 10 micrograms TCDD/kg. Animals were treated again at the time of surgery… CONTINUE READING
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