Corpus ID: 4861648

Promotion of corneal allograft survival with leflunomide.

@article{Niederkorn1994PromotionOC,
  title={Promotion of corneal allograft survival with leflunomide.},
  author={Jerry Y. Niederkorn and Laura Smith Lang and J R Ross and J Mellon and Stella M Robertson},
  journal={Investigative ophthalmology \& visual science},
  year={1994},
  volume={35 10},
  pages={
          3783-5
        }
}
PURPOSE The efficacy of the antirejection drug leflunomide was evaluated in a rat model of penetrating keratoplasty. METHODS Corneal grafts from inbred Lewis rats were transplanted orthotopically to inbred Wistar-Furth (WF) recipients. WF rats received either Leflunomide (HWA 486), the active metabolite of leflunomide (A77-1726A), or cyclosporin A, administered orally beginning 2 days before transplantation and continuing for 30 days thereafter. Graft survival was assessed clinically three… Expand
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