Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1.

@article{Zhao2010PromotionOC,
  title={Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1.},
  author={Liang Zhao and Hui Wang and Chao Liu and Yawei Liu and Xiaoyan Wang and Shuang Wang and Xuegang Sun and Jianming Li and Yongjian Deng and Yong Jiang and Yanqing Ding},
  journal={Gut},
  year={2010},
  volume={59 9},
  pages={1226-35}
}
BACKGROUND LIM and SH3 protein 1 (LASP-1), initially identified from a cDNA library of metastatic axillary lymph nodes of breast cancer patients, is a specific focal adhesion protein involved in numerous biological and pathological processes. The overexpression of LASP-1 has been described in several types of cancers, but the role of LASP-1 in colorectal cancer (CRC) is unknown. In a previous study, comparative proteomic analysis was performed and LASP-1 was identified as a CRC-associated… CONTINUE READING