Promotion of Erythropoietic Differentiation in Hematopoietic Stem Cells by SOCS3 Knock-Down

@inproceedings{Liu2015PromotionOE,
  title={Promotion of Erythropoietic Differentiation in Hematopoietic Stem Cells by SOCS3 Knock-Down},
  author={Yu-xiao Liu and Xing Shui Dong and Feng Ying Gong and Ning Fen Su and Su-bo Li and Hai-Tao Zhang and Jia-ling Liu and Jing-hui Xue and Shou-ping Ji and Zhi–wen Zhang and T. Papayannopoulou},
  booktitle={PloS one},
  year={2015}
}
Suppressor of cytokine signaling 3 (SOCS3) plays an important role in mice fetal liver erythropoiesis, but the roles of SOCS3 in human hematopoietic stem cells (HSCs) have not been well investigated. In the present study, lentiviral small interference RNA expression vectors (shRNA) of SOCS3 were constructed and stably transferred into HSCs. We found that SOCS3 knockdown induced erythroid expansion in HSCs. Conversely, Ectopic expression of SOCS3 in progenitor cells blocked erythroid expansion… CONTINUE READING
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