Promotion effect of immobilized chondroitin sulfate on intrafibrillar mineralization of collagen.

@article{He2020PromotionEO,
  title={Promotion effect of immobilized chondroitin sulfate on intrafibrillar mineralization of collagen.},
  author={Huihui He and Changyu Shao and Zhao Mu and Caiyun Mao and Jian Sun and Chaoqun Chen and Ruikang Tang and Xin-hua Gu},
  journal={Carbohydrate polymers},
  year={2020},
  volume={229},
  pages={
          115547
        }
}
  • Huihui He, Changyu Shao, +5 authors Xin-hua Gu
  • Published in Carbohydrate polymers 2020
  • Chemistry, Medicine
  • Chondroitin sulfate (CS) is widespread in mineralized tissues and is considered to play crucial roles during the mineralization process. However, its role in biomineralization remains controversial. In the present study, CS is immobilized to collagen fibrils to mimic its state in biomineralization. The results demonstrate that immobilized CS on collagen fibrils accelerates calcium phosphate nucleation and significantly promotes collagen mineralization by accumulating calcium ions in collagen… CONTINUE READING

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