Promotion and maintenance of leukemia by ERG.

  title={Promotion and maintenance of leukemia by ERG.},
  author={Shinobu Tsuzuki and Osamu Taguchi and Masao Seto},
  volume={117 14},
The Ets-related gene (ERG) located on human chromosome 21 encodes a transcription factor and is thought to be causally related to Down syndrome-associated acute megakaryocytic leukemia in childhood. In clinical adult leukemia, however, increased expression of ERG is indicative of poor prognosis in T-cell acute lymphoblastic leukemia and cytogenetically normal acute myeloid leukemia, although the involvement of ERG in the development of adult leukemia remains elusive. Here, we show that forced… CONTINUE READING


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