• Corpus ID: 195808231

Promoting stone fruits for Protection against the Metabolic Syndrome

  title={Promoting stone fruits for Protection against the Metabolic Syndrome},
  author={Leader and Dr. Luis Cisneros-Zevallos},



Medicinal chemistry approaches for glucokinase activation to treat type 2 diabetes.

  • M. Pal
  • Biology, Medicine
    Current medicinal chemistry
  • 2009
With the promising preclinical data in hand, GK activators represent a promising and new treatment option for T2D.

Prolonged Treatment of Primary Hepatocytes with Oleate Induces Insulin Resistance through p38 Mitogen-activated Protein Kinase*

A critical role for p38 in oleate-induced hepatic insulin resistance is demonstrated and a prolonged treatment of primary hepatocytes with oleates blunted insulin suppression of hepatic gluconeogenesis, and decreased insulin-induced phosphorylation of Akt in a p38-dependent manner.

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells*

A model of cellular lipid metabolism in which oleate protects against palmitate-induced inflammation and insulin resistance in skeletal muscle cells by promoting triglyceride accumulation and mitochondrial β-oxidation through PPARα- and protein kinase A-dependent mechanisms is supported.

Toll-like Receptor-2 Is Essential for the Development of Palmitate-induced Insulin Resistance in Myotubes*

  • J. Senn
  • Biology
    Journal of Biological Chemistry
  • 2006
RNA interference-mediated inhibition of TLR2 and MyD88 expression in C2C12 muscle cells resulted in a near complete inhibition of palmitate-induced insulin resistance and interleukin (IL)-6 production.

Antidiabetic activity of alcoholic stem extract of Gymnema montanum in streptozotocin-induced diabetic rats.

Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscle.

It is suggested that metformin can activate I2BR to increase glucose uptake and I2 BR will be a new target for diabetic therapy.

Liver glucokinase: decreased activity in patients with type II diabetes.

Glucokinase activity was decreased by about 50% in obese subjects with diabetes compared with lean controls and obese controls, which further support the important role that glucokinase plays in the pathogenesis of Type II diabetes.

Liver glucokinase: An overview on the regulatorymechanisms of its activity

This work summarizes the current knowledge regarding the regulation of hepatic GCK activity and describes how this activity is modulated through a complex set of mechanisms.