Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair.

@article{Galtrey2007PromotingPI,
  title={Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair.},
  author={Clare M. Galtrey and Richard A. Asher and Fatiha Nothias and James W. Fawcett},
  journal={Brain : a journal of neurology},
  year={2007},
  volume={130 Pt 4},
  pages={926-39}
}
Functional recovery after peripheral nerve repair in humans is often disappointing. A major reason for this is the inaccuracy of re-innervation of muscles and sensory structures. We hypothesized that promoting plasticity in the spinal cord, through digestion of chondroitin sulphate proteoglycans (CSPGs) with chondroitinase ABC (ChABC), might allow the CNS to compensate for inaccurate peripheral re-innervation and improve functional recovery. The median and ulnar nerves were injured and repaired… CONTINUE READING
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