Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype

@inproceedings{Kellner2013PromotingNK,
  title={Promoting natural killer cell functions by recombinant immunoligands mimicking an induced self phenotype},
  author={Christian Johannes Kellner and Martin Gramatzki and Matthias Peipp},
  booktitle={Oncoimmunology},
  year={2013}
}
Immunoligands for stimulatory natural killer (NK)-cell receptors can be targeted to the surface of malignant cells by fusing them to antibody fragments. Mimicking an "induced-self" phenotype, such recombinant immunoligands signal danger, trigger NK-cell cytotoxicity and synergistically enhance antibody-dependent cellular cytotoxicity. These findings may be translated into novel immunotherapeutic approaches against cancer. 

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