Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.

@article{Gupta2014PromotingMA,
  title={Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.},
  author={Kamlesh Kumar Gupta and Emily O Alberico and Inke S. N{\"a}thke and Holly V. Goodson},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2014},
  volume={36 9},
  pages={818-26}
}
Regulation of microtubule (MT) dynamics is essential for many cellular processes, but the machinery that controls MT dynamics remains poorly understood. MT plus-end tracking proteins (+TIPs) are a set of MT-associated proteins that dynamically track growing MT ends and are uniquely positioned to govern MT dynamics. +TIPs associate with each other in a complex array of inter- and intra-molecular interactions known as the "+TIP network." Why do so many +TIPs bind to other +TIPs? Typical answers… CONTINUE READING
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