Promoting effects of serotonin on hematopoiesis: ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis.

@article{Yang2007PromotingEO,
  title={Promoting effects of serotonin on hematopoiesis: ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis.},
  author={Mo Yang and Karen Li and Pak Cheung Ng and Carmen Ka Yee Chuen and Tze Kin Lau and Yuan Shan Cheng and Yuan Sheng Liu and Chi K Li and Patrick Man Pan Yuen and Anthony Edward James and Shuk Man Lee and Tai Fai Fok},
  journal={Stem cells},
  year={2007},
  volume={25 7},
  pages={1800-6}
}
Serotonin is a monoamine neurotransmitter that has multiple extraneuronal functions. We previously reported that serotonin exerted mitogenic stimulation on megakaryocytopoiesis mediated by 5-hydroxytryptamine (5-HT)2 receptors. In this study, we investigated effects of serotonin on ex vivo expansion of human cord blood CD34+ cells, bone marrow (BM) stromal cell colony-forming unit-fibroblast (CFU-F) formation, and antiapoptosis of megakaryoblastic M-07e cells. Our results showed that serotonin… CONTINUE READING