Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast.

@article{Metzger1992PromoterSO,
  title={Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast.},
  author={Daniel Metzger and R{\'e}gine Losson and J M Bornert and Yves Lemoine and Pierre Chambon},
  journal={Nucleic acids research},
  year={1992},
  volume={20 11},
  pages={2813-7}
}
We have previously demonstrated that the human oestrogen receptor (hER) contains two transcriptional activation functions located in the N-terminal region (TAF-1) and in the hormone binding domain (TAF-2), which can act both independently and synergistically in a promoter- and cell-specific manner in animal cells. We have also demonstrated that hER can activate transcription from chimaeric oestrogen-responsive GAL1 promoters in yeast, and shown that transcriptional activation was due to TAF-1… CONTINUE READING