Promoter specificity for 6S RNA regulation of transcription is determined by core promoter sequences and competition for region 4.2 of sigma70.

@article{Cavanagh2008PromoterSF,
  title={Promoter specificity for 6S RNA regulation of transcription is determined by core promoter sequences and competition for region 4.2 of sigma70.},
  author={Amy T. Cavanagh and Andrew D. Klocko and Xiaochun Liu and Karen Montzka Wassarman},
  journal={Molecular microbiology},
  year={2008},
  volume={67 6},
  pages={1242-56}
}
6S RNA binds sigma70-RNA polymerase and downregulates transcription at many sigma70-dependent promoters, but others escape regulation even during stationary phase when the majority of the transcription machinery is bound by the RNA. We report that core promoter elements determine this promoter specificity; a weak -35 element allows a promoter to be 6S RNA sensitive, and an extended -10 element similarly determines 6S RNA inhibition except when a consensus -35 element is present. These two… CONTINUE READING