Promoter-specific imprinting of the human insulin-like growth factor-II gene


GENOMIC imprinting is a mechanism whereby only one of the two parental alleles is expressed. Loss or relaxation of genomic imprinting has been proposed as an epigenetic mechanism for oncogenesis in a variety of human tumours1–6. Although the mechanism of imprinting is unknown, differential CpG methylation of the parental alleles has been implicated7–12. The… (More)
DOI: 10.1038/371714a0


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