Promoter-region alleles of the TNF-alpha and IL-10 genes have no effect on pretransplant alloantibody production.

@article{Hahn2001PromoterregionAO,
  title={Promoter-region alleles of the TNF-alpha and IL-10 genes have no effect on pretransplant alloantibody production.},
  author={Amy B. Hahn and Jane C Kasten-Jolly and D M Constantino and Eileen M Graffunder and David Conti},
  journal={Transplantation},
  year={2001},
  volume={72 4},
  pages={739-42}
}
BACKGROUND The presence of high levels of alloantibodies are known to be a risk factor in renal graft outcome. Expression level polymorphisms in cytokine genes are also thought to have an effect on allograft outcome, but the studies examining this have been inconsistent. This may be due to center-specific differences in immunosuppressive protocols. Therefore, we studied the effects of these polymorphisms on pretransplant class I alloantibody production in nonexogenously immunosuppressed… CONTINUE READING