Promoter recognition by Escherichia coli RNA polymerase. Role of the spacer DNA in functional complex formation.


The available evidence suggests that during the process of formation of a functional or "open" complex at a promoter, Escherichia coli RNA polymerase transiently realigns the two contacted regions of the promoter, thus stressing the intervening spacer DNA. We tested the possibility that this process plays an active role in the formation of an open complex… (More)


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