Promoter polymorphisms and methylation of E-cadherin (CDH1) and KIT in gastric cancer patients from northern Brazil.

@article{Borges2010PromoterPA,
  title={Promoter polymorphisms and methylation of E-cadherin (CDH1) and KIT in gastric cancer patients from northern Brazil.},
  author={B N Borges and Erivelton da Silva Santos and Carlos Eduardo Matos Carvalho Bastos and Laine Celestino Pinto and Nilson Praia Anselmo and Juarez Ant{\^o}nio Sim{\~o}es Quaresma and Danielle Queiroz Calcagno and Rommel M{\'a}rio Rodr{\'i}guez Burbano and Maria L{\'u}cia Harada},
  journal={Anticancer research},
  year={2010},
  volume={30 6},
  pages={
          2225-33
        }
}
UNLABELLED The aim of this study was to verify genetic and epigenetic alterations in gastric cancer patients from Pará state, northern Brazil. MATERIALS AND METHODS Exon 11 of KIT and two promoter polymorphisms (-160 C/A and -347 G/GA) of the E-cadherin gene (CDH1), and their correlation with the promoter methylation status were analyzed. RESULTS No genetic alterations in KIT were found. Promoter polymorphisms revealed an increased probability of developing gastric cancer, especially of the… CONTINUE READING
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