Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis.

Abstract

AIM To elucidate the possible difference in two promoter polymorphisms of the transforming growth factor-beta1 (TGF-beta1) gene (-800G > A, -509C > T) between ulcerative colitis (UC) patients and normal subjects. METHODS A total of 155 patients with established ulcerative colitis and 139 normal subjects were selected as controls. Two single nucleotide polymorphisms within the promoter region of TGF-beta1 gene (-509C > T and -800G > A) were genotyped using PCR-RFLP. RESULTS There was a statistically significant difference in genotype and allele frequency distributions between UC patients and controls for the -800G > A polymorphism of the TGF-beta1 gene (P < 0.05). The frequency of the TGF-beta1 gene polymorphism at position -800 showed that the AA genotype and the allele A frequencies significantly differed between the patients and healthy controls (P < 0.05). At position -509, there was no statically significant difference in genotype and allele frequency between the patients and control subjects. CONCLUSION The results of our study indicate that there is a significant difference in both allele and genotype frequency at position -800G > A of TGF-beta1 gene promoter between Iranian patients with UC and normal subjects.

Cite this paper

@article{Tamizifar2008PromoterPO, title={Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis.}, author={Babak Tamizifar and Kamran Bagheri Lankarani and Sirous Naeimi and M Rismankar Zadeh and Ali Reza Taghavi and Abbas Ali Ghaderi}, journal={World journal of gastroenterology}, year={2008}, volume={14 2}, pages={243-7} }