Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 5A/6A) in development of HAND and modulation of pathogenesis of HAND

@article{Singh2017PromoterPM,
  title={Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 5A/6A) in development of HAND and modulation of pathogenesis of HAND},
  author={Hari Om Singh and Shruti D Marathe and Sumitra Nain and Dharmesh Samani and Vijay Nema and Manisha V Ghate and Raman Raghunathrao Gangakhedkar},
  journal={Journal of Biosciences},
  year={2017},
  volume={42},
  pages={481-490}
}
The pathogenesis of HIV-associated neurocognitive disorder (HAND) is modulated by host genetic susceptibility factors such as Matrix metalloproteinases (MMPs). Promoter polymorphism of MMP-1 and MMP-3 may modify the expression of the gene. Hence, we evaluated the association of MMP-1-16072G/1G and MMP-3-1612 5A/6A polymorphisms with development of HAND and the modulation of pathogenesis of HAND. We enrolled a total of 180 individuals, 50 HIV-infected individuals with HAND, 130 without HAND, and… CONTINUE READING
BETA

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Role of Interstitial Collagenase Gene Promoter Polymorphism in the Etiology of Gastric Cancer

  • Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • 2014
VIEW 1 EXCERPT

Screening for cognitive impairment in human immunodeficiency virus.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2011
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…