Promoter polymorphism (–491A/T) in the APOE gene of Finnish Alzheimer’s disease patients and control individuals

Abstract

Apolipoprotein E (APOE) ɛ4 allele is a major risk factor for the development of Alzheimer’s disease (AD). It has been suggested that the quantitative expression of APOE alleles results from mutations in the promoter region of this gene. We studied the –491A/T promoter polymorphism and whether it is dependent on the APOE ɛ4 allele in clinic-based AD (n = 106… (More)
DOI: 10.1007/s004150050461

Topics

2 Figures and Tables