Promoter or enhancer, what's the difference? Deconstruction of established distinctions and presentation of a unifying model.

@article{Andersson2015PromoterOE,
  title={Promoter or enhancer, what's the difference? Deconstruction of established distinctions and presentation of a unifying model.},
  author={Robin Andersson},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2015},
  volume={37 3},
  pages={314-23}
}
Gene transcription is strictly controlled by the interplay of regulatory events at gene promoters and gene-distal regulatory elements called enhancers. Despite extensive studies of enhancers, we still have a very limited understanding of their mechanisms of action and their restricted spatio-temporal activities. A better understanding would ultimately lead to fundamental insights into the control of gene transcription and the action of regulatory genetic variants involved in disease. Here, I… CONTINUE READING
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