Promoter occlusion: transcription through a promoter may inhibit its activity.

@article{Adhya1982PromoterOT,
  title={Promoter occlusion: transcription through a promoter may inhibit its activity.},
  author={Sankar 8 Adhya and Max E. Gottesman},
  journal={Cell},
  year={1982},
  volume={29 3},
  pages={939-44}
}
Induction of prophage lambda inhibits the expression of the gal operon from its cognate promoters. The effect is observed only in cis, and is due to frequent transcription of the gal promoter region by RNA polymerase molecules initiating upstream at the prophage PL promoter. The frequency of transcription initiation at PL is some 30 times greater than that at the gal promoter, Pg1. PL is one of the strongest procaryotic promoters. This "promoter occlusion" is essentially complete when the… CONTINUE READING

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