Promoter microsatellites as modulators of human gene expression.

@article{Sawaya2012PromoterMA,
  title={Promoter microsatellites as modulators of human gene expression.},
  author={Sterling Sawaya and Andrew T. M. Bagshaw and Emmanuel Buschiazzo and N. Gemmell},
  journal={Advances in experimental medicine and biology},
  year={2012},
  volume={769},
  pages={
          41-54
        }
}
Microsatellites in and around genes have been shown to modulate levels of gene expression in multiple organisms, ranging from bacteria to humans. Here we will discuss promoter microsatellites known to modulate gene expression, with a few key examples related to the human brain. Many of the microsatellites we discuss are highly conserved in mammals, indicating that selection may favor their retention as "tuning knobs" of gene expression. We will also discuss the mechanisms by which… Expand
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