Promoter methylation status of the FHIT gene and Fhit expression: association with HER2/neu status in breast cancer patients.

@article{Jeong2013PromoterMS,
  title={Promoter methylation status of the FHIT gene and Fhit expression: association with HER2/neu status in breast cancer patients.},
  author={Y. Jeong and H-Y Jeong and Sang Min Lee and J. Bong and Sung Hwan Park and H. Oh},
  journal={Oncology reports},
  year={2013},
  volume={30 5},
  pages={
          2270-8
        }
}
Aberrant DNA methylation has been recognized to contribute to breast carcinogenesis, and promoter hypermethylation of several tumor suppressor genes has been correlated with decreased gene expression. The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene in breast and other types of cancer, and loss of Fhit expression has been observed in breast cancer. The aim of the present study was to evaluate the association between methylation of the FHIT gene and its expression in… Expand
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References

SHOWING 1-10 OF 38 REFERENCES
Promoter Hypermethylation in Tumor Suppressing Genes p16 and FHIT and Their Relationship with Estrogen Receptor and Progesterone Receptor Status in Breast Cancer Patients from Northern India.
TLDR
The authors did not find any significant differences in tumor-related gene methylation patterns relevant to both ER and PR status of breast tumors, and showed significant harmony in concordant hypermethylation in postmenopausal patients. Expand
Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir.
TLDR
It is provided the first evidence to the authors' knowledge that the significant association of FHIT mutation and hypermethylation leads to the complete inactivation of F HIT gene in patients with breast cancer. Expand
Loss of FHIT Expression in Breast Cancer Is Correlated with Poor Prognostic Markers
TLDR
The results suggest that loss of FHIT expression in breast cancer is associated with poor prognostic features and needs to be further evaluated in larger trials with longer follow-up. Expand
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
TLDR
It is concluded that methylation of FHIT is a frequent event in NSCLC and breast cancers and is an important mechanism for loss of expression of this gene. Expand
Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer.
TLDR
Data support the view that in addition to HER-2/neu-associated signaling, epigenetic changes in cancer as well as in tumor stroma cells might attribute to the specific biological features of HER- 2/NEu-positive cancers. Expand
Association of Breast Cancer DNA Methylation Profiles with Hormone Receptor Status and Response to Tamoxifen
TLDR
The results reveal an as yet unrecognized degree of interaction between DNA methylation and HR biology in breast cancer cells and suggest potentially clinically useful novel DNAmethylation predictors of response to hormonal and non-hormonal breast cancer therapy. Expand
Specific 50'CpG island methylation signatures of FHIT and p16 genes and their potential diagnostic relevance in Indian breast cancer patients.
TLDR
Analysis of methylation signatures from 232 primary sporadic breast cancer patients illustrated that hypermethylation of FHIT gene and p16 gene may be used as a potential diagnostic marker to diagnose the early and locally advanced stages of breast cancer. Expand
Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.
TLDR
The results suggest that the methylation profile may be a potential new biomarker of risk prediction in bladder cancer and that CDH1 methylation positive status was independently associated with poor survival in multivariate analyses. Expand
Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer.
TLDR
This study provides the first evidence that biallelic inactivation by LOH and hypermethylation leads to the complete inactivation of FHIT gene in patients with breast cancer. Expand
Estrogen and progesterone receptor status affect genome-wide DNA methylation profile in breast cancer.
TLDR
It is found that ER/PR status affects the DNA methylation state of FAM124B, ST6GALNAC1, NAV1 and PER1 in breast cancer. Expand
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