Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma–carcinoma sequence

@article{Lee2011PromoterMS,
  title={Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma–carcinoma sequence},
  author={K. Lee and Ji-Shin Lee and J. Nam and C. Choi and M. Lee and C. Park and S. Juhng and J. Lee},
  journal={Langenbeck's Archives of Surgery},
  year={2011},
  volume={396},
  pages={1017-1026}
}
  • K. Lee, Ji-Shin Lee, +5 authors J. Lee
  • Published 2011
  • Medicine
  • Langenbeck's Archives of Surgery
  • PurposeEpigenetic silencing of the DNA mismatch repair genes has been poorly described in colorectal carcinomas showing the classic adenoma–carcinoma pathway of carcinogenesis. The aim of this study was to investigate the methylation status of MutL homolog 1 (hMLH1), MutS homolog 2 (hMSH2), and O-6-methylguanine-DNA methyltransferase (MGMT) in a series of colorectal carcinomas that contain both adenomas and carcinomas.MethodsPromoter methylation of hMLH1, hMSH2, and MGMT was evaluated in normal… CONTINUE READING
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