Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer

@article{KohonenCorish2007PromoterMO,
  title={Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer},
  author={Maija R J Kohonen-Corish and Nicholas D Sigglekow and Jimmy Tandiono Susanto and Pierre H. Chapuis and Elie L Bokey and O F Dent and Christina Chan and B. Paul Lin and Tan Jia Seng and Peter W. Laird and Joanne Alison Young and BarbaraA. Leggett and Jeremy R. Jass and Robert Lyndsay Sutherland},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={4435-4441}
}
The mutated in colorectal cancer (MCC) gene is in close linkage with the adenomatous polyposis coli (APC) gene on chromosome 5, in a region of frequent loss of heterozygosity in colorectal cancer. The role of MCC in carcinogenesis, however, has not been extensively analysed, and functional studies are emerging, which implicate it as a candidate tumor suppressor gene. The aim of this study was to examine loss of MCC expression due to promoter hypermethylation and its clinicopathologic… CONTINUE READING
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