Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma.

@article{Tzao2005PromoterMO,
  title={Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma.},
  author={Ching Tzao and Han-Sui Hsu and Guang-Huan Sun and Hsiao-Lei Lai and Ying-Jan Wang and H Tung and Cheng-Ping Yu and Y L Cheng and S F Lee},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2005},
  volume={130 5},
  pages={1371}
}
OBJECTIVE Aberrant expression of mismatch repair genes, such as human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2), are common in some human cancers, and promoter methylation is believed to inactivate expression of hMLH1. We investigated whether promoter methylation is involved in loss of hMLH1 protein and whether aberrant expression of hMLH1 and hMSH2 protein is related to prognosis after resection for esophageal squamous cell cancer. METHODS We analyzed promoter methylation of… CONTINUE READING

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