Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers.

  title={Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers.},
  author={Chang Kyoo Sung and Dawei Li and Erik Andrews and Ronny Drapkin and Thomas L. Benjamin},
  journal={Molecular oncology},
  volume={7 3},
The SALL2 gene product and transcription factor p150 were first identified in a search for tumor suppressors targeted for inactivation by the oncogenic mouse polyoma virus. SALL2 has also been identified as a cellular quiescence factor, essential for cells to enter and remain in a state of growth arrest under conditions of serum deprivation. p150 is a transcriptional activator of p21(Cip1/Waf1) and BAX, sharing important growth arrest and proapoptotic properties with p53. It also acts as a… CONTINUE READING
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