Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas.

@article{Pinto2003PromoterMO,
  title={Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas.},
  author={Mafalda Pinto and Carla M Oliveira and Lu{\'i}s Cirnes and Jos{\'e} Carlos Machado and Maria Ramires and Ana Nogueira and F{\'a}tima Carneiro and Raquel Seruca},
  journal={The Journal of pathology},
  year={2003},
  volume={200 1},
  pages={32-8}
}
Transforming growth factor beta (TGFbeta) is a potent inhibitor of cell growth, whose action is transduced through interaction between type I (RI) and type II (RII) receptors. Abnormal expression of these receptors has been identified in several human cancers and was found to be associated with resistance to TGFbeta. TGFbeta RII mutations occur in many types of malignancy. TGFbeta RI hypermethylation has been suggested as a cause of abnormal or absent expression of this receptor in cancer. This… CONTINUE READING