Promoter methylation-mediated downregulation of PRDM5 contributes to the development of lung squamous cell carcinoma

Abstract

PRDM5 has been proposed as a tumor suppressor frequently downregualted in tumor. In this study, lung squamous cell carcinoma tissues and adjacent nontumorous normal tissues were collected from 30 patients. PRDM5 expression was detected by reverse transcription polymerase chain reaction and Western blot analysis, DNA methylation of PRDM5 promoter was… (More)
DOI: 10.1007/s13277-013-1593-2

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