Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.

@article{Virmani2000PromoterMA,
  title={Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.},
  author={Arvind K. Virmani and Asha Rathi and Sabine Zoechbauer-Mueller and Nicoletta Sacchi and Yasuro Fukuyama and David A Bryant and Anirban Maitra and Shashank Heda and Kwun Meng Fong and Frederik B. J. M. Thunnissen and John D. Minna and Adi F. Gazdar},
  journal={Journal of the National Cancer Institute},
  year={2000},
  volume={92 16},
  pages={1303-7}
}
BACKGROUND Retinoic acid plays an important role in lung development and differentiation, acting primarily via nuclear receptors encoded by the retinoic acid receptor-beta (RARbeta) gene. Because receptor isoforms RARbeta2 and RARbeta4 are repressed in human lung cancers, we investigated whether methylation of their promoter, P2, might lead to silencing of the RARbeta gene in human lung tumors and cell lines. METHODS Methylation of the P2 promoter from small-cell lung cancer (SCLC) and non… CONTINUE READING
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  • J Berard, F Laboune, M Mukuna, S Masse, R Kothary, WE Bradley
  • 2000

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