Promoter methylation and loss of p16INK4a gene expression in head and neck cancer

  title={Promoter methylation and loss of p16INK4a gene expression in head and neck cancer},
  author={Semra Demokan and Alice Y. Chuang and Yusufhan Suoğlu and Murat Ulusan and Zubeyde Yalniz and Joseph A. Califano and Nejat Dalay},
  journal={Head \& Neck},
Silencing of tumor suppressor genes plays a vital role in head and neck carcinogenesis. In this study we aimed to evaluate aberrant p16INK4a gene promoter methylation in patients with head and neck cancer. 

State of methylation and epigenome studies in some types of head and neck cancer

The main purpose of this study is to review the methylation promoter genes in OSCC and to determine the degree of methylation in these types of tumors, in addition to analyzing the latest studies on the usefulness of these genes as epigenetic markers for early detection and to determined the recurrence of the disease and offer new treatment options.

Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy

Genes regulated by methylation play a modulatory function in HNC susceptibility and it represent a critical therapeutic target to manage patients with advanced disease.

Expression OF p16INK4a Gene in Premalignant and Malignant Lesions of Oral Cavity

The p16 staining was correlated between the control and study groups and p 16 was shown to be increasing expressed in premalignant and less expressed in malignant category and was found to be statistically significant by Fischer's exact test.

Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies

A meta-analysis of 21 published studies identified that aberrant methylation of p16INK4a promoter was found to be significantly associated with HNSCC.

The Association and Clinical Significance of CDKN2A Promoter Methylation in Head and Neck Squamous Cell Carcinoma: a Meta-Analysis

Findings indicate CDKN2A methylation is involved in the carcinogenesis, progression, and metastasis of HNSCC and could be a potential diagnostic and prognostic biomarker for H NSCC.

Promoter DNA Methylation and mRNA Expression Level of p16 Gene in Oral Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics

It appears that P16 status is useful for classifying patients with OSCC and for influencing treatment strategies in accordance with this classification, and targeting the upregulation of p16 could be a promising therapeutic option.

Validation of methylation markers for diagnosis of oral cavity cancer.

Aberrant epigenetic modifications in radiation-resistant head and neck cancers.

This chapter intends to establish an in vitro model for investigating DNA methylation changes in IR-resistant head and neck cancer cells, and Bisulfite pyrosequencing is the main methodology it introduced.

Salivary epigenetic biomarkers in head and neck squamous cell carcinomas.

This review will focus on two commonly aberrant epigenetic alterations: DNA methylation and microRNA expression in HNSCC and their potential clinical utility.



The methylation status and protein expression of CDH1, p16INK4A, and fragile histidine triad in nonsmall cell lung carcinoma

Investigation of the inactivation of genes and prognostic factors in patients with nonsmall cell lung carcinoma by examining resection samples for the presence of methylation finds methylation in CpG island.

Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma

  • K. FukaiO. Yokosuka H. Saisho
  • Medicine, Biology
    Liver international : official journal of the International Association for the Study of the Liver
  • 2005
The INK4 locus consisting of three genes involved in the regulation of cell cycle, p16INK4a, p15INK4b, and p14ARF is often disrupted in human neoplasms.

Role of DNA methylation in head and neck cancer

This review aimed to analyze the available information indicating a role for the epigenetic changes in HNC, and found that methylation analysis may provide promising clinical applications, including the development of new biomarkers and prediction of the therapeutic response or prognosis.

Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan.

Aberrant methylation of EDNRB and p16 genes is highly prevalent in HCC and it is suggested that epigenetic alteration of these two genes may play an important role in the pathogenesis of HCC.

Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area

Analysis of patients dietary habits revealed a strong association between promoter methylation and high consumption of hot salted tea (P < 0.05) which is a most favourite drink commonly consumed by Kashmiri people.

Promoter methylation of p16, DAPK, CDH1, and TIMP‐3 genes in cervical cancer: correlation with clinicopathologic characteristics

  • D. JeongM. Youm K. Kim
  • Medicine
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • 2006
The promoter methylation of the p16 gene is a frequent event in cervical carcinogenesis and may have potential clinical application as a marker for the progression and prognosis of cancer.

p16 gene methylation in colorectal cancers associated with Duke's staging.

AIM To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers. METHODS

Simultaneous methylation profiling of tumor suppressor genes in head and neck cancer.

The results indicate that methylation of tumor suppressor genes is not high as previously reported by methylation-specific polymerase chain reaction and is confined to a smaller but significant fraction of the tumors.

DNA methylation and loss of protein expression in esophageal squamous cell carcinogenesis of high-risk area.

Results indicate that p16 and FHIT methylation may be one of the earliest events and an important mechanism for gene silencing in esophageal squamous cell carcinogenesis and may be helpful for screening the candidate molecular markers for early diagnosis of ESCC in high-risk area.

Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma.