Promoter methylation and loss of p16INK4a gene expression in head and neck cancer

@article{Demokan2012PromoterMA,
  title={Promoter methylation and loss of p16INK4a gene expression in head and neck cancer},
  author={Semra Demokan and Alice Chuang and Yusufhan Suoğlu and Murat Ulusan and Zubeyde Yalniz and Joseph A. Califano and Nejat Dalay},
  journal={Head \& Neck},
  year={2012},
  volume={34}
}
Silencing of tumor suppressor genes plays a vital role in head and neck carcinogenesis. In this study we aimed to evaluate aberrant p16INK4a gene promoter methylation in patients with head and neck cancer. 
State of methylation and epigenome studies in some types of head and neck cancer
TLDR
The main purpose of this study is to review the methylation promoter genes in OSCC and to determine the degree of methylation in these types of tumors, in addition to analyzing the latest studies on the usefulness of these genes as epigenetic markers for early detection and to determined the recurrence of the disease and offer new treatment options. Expand
Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy
TLDR
Genes regulated by methylation play a modulatory function in HNC susceptibility and it represent a critical therapeutic target to manage patients with advanced disease. Expand
Expression OF p16INK4a Gene in Premalignant and Malignant Lesions of Oral Cavity
TLDR
The p16 staining was correlated between the control and study groups and p 16 was shown to be increasing expressed in premalignant and less expressed in malignant category and was found to be statistically significant by Fischer's exact test. Expand
Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies
TLDR
A meta-analysis of 21 published studies identified that aberrant methylation of p16INK4a promoter was found to be significantly associated with HNSCC. Expand
The Association and Clinical Significance of CDKN2A Promoter Methylation in Head and Neck Squamous Cell Carcinoma: a Meta-Analysis
TLDR
Findings indicate CDKN2A methylation is involved in the carcinogenesis, progression, and metastasis of HNSCC and could be a potential diagnostic and prognostic biomarker for H NSCC. Expand
Promoter DNA Methylation and mRNA Expression Level of p16 Gene in Oral Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics
TLDR
It appears that P16 status is useful for classifying patients with OSCC and for influencing treatment strategies in accordance with this classification, and targeting the upregulation of p16 could be a promising therapeutic option. Expand
Validation of methylation markers for diagnosis of oral cavity cancer.
TLDR
The pursuing of this panel of hypermethylated genes is an important tool for the detection of individuals with OSCC and the identification of these markers in early stages of OSCC shows the feasibility of using the panel on saliva as possible biomarkers for early diagnosis. Expand
Methylation as a biomarker for head and neck cancer.
TLDR
Assuming that cancer results from genetic and epigenetic changes, analyzes based on gene methylation profile in combination with the pathological diagnosis would be useful in predicting the behavior of these head and neck tumors. Expand
Aberrant epigenetic modifications in radiation-resistant head and neck cancers.
TLDR
This chapter intends to establish an in vitro model for investigating DNA methylation changes in IR-resistant head and neck cancer cells, and Bisulfite pyrosequencing is the main methodology it introduced. Expand
Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome
TLDR
It is demonstrated that CD KN2A alteration is a frequent event in OTSCC tumourigenesis, however, no correlation was identified between different potential mechanisms of CDKN2A disruption and clinical characteristics or patient outcome. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 80 REFERENCES
The methylation status and protein expression of CDH1, p16INK4A, and fragile histidine triad in nonsmall cell lung carcinoma
TLDR
Investigation of the inactivation of genes and prognostic factors in patients with nonsmall cell lung carcinoma by examining resection samples for the presence of methylation finds methylation in CpG island. Expand
Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma
  • K. Fukai, O. Yokosuka, +5 authors H. Saisho
  • Biology, Medicine
  • Liver international : official journal of the International Association for the Study of the Liver
  • 2005
TLDR
The INK4 locus consisting of three genes involved in the regulation of cell cycle, p16INK4a, p15INK4b, and p14ARF is often disrupted in human neoplasms. Expand
Role of DNA methylation in head and neck cancer
TLDR
This review aimed to analyze the available information indicating a role for the epigenetic changes in HNC, and found that methylation analysis may provide promising clinical applications, including the development of new biomarkers and prediction of the therapeutic response or prognosis. Expand
Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan.
TLDR
Aberrant methylation of EDNRB and p16 genes is highly prevalent in HCC and it is suggested that epigenetic alteration of these two genes may play an important role in the pathogenesis of HCC. Expand
Differential impact of p16 inactivation by promoter methylation in non-small cell lung and colorectal cancer: clinical implications.
TLDR
It is indicated that p16 alterations constitute a major molecular abnormality in NSCLC with a considerable prognosis impact, promoter methylation being an important mechanism involved in p16 silencing. Expand
Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area
TLDR
Analysis of patients dietary habits revealed a strong association between promoter methylation and high consumption of hot salted tea (P < 0.05) which is a most favourite drink commonly consumed by Kashmiri people. Expand
Promoter methylation of p16, DAPK, CDH1, and TIMP‐3 genes in cervical cancer: correlation with clinicopathologic characteristics
  • D. Jeong, M. Youm, +4 authors K. Kim
  • Medicine
  • International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • 2006
TLDR
The promoter methylation of the p16 gene is a frequent event in cervical carcinogenesis and may have potential clinical application as a marker for the progression and prognosis of cancer. Expand
p16 gene methylation in colorectal cancers associated with Duke's staging.
AIM To explore the association of methylation of the CpG island in the promotor of the p16 tumor suppressor gene with the clinicopathological characteristics of the colorectal cancers. METHODSExpand
Simultaneous methylation profiling of tumor suppressor genes in head and neck cancer.
TLDR
The results indicate that methylation of tumor suppressor genes is not high as previously reported by methylation-specific polymerase chain reaction and is confined to a smaller but significant fraction of the tumors. Expand
DNA methylation and loss of protein expression in esophageal squamous cell carcinogenesis of high-risk area.
TLDR
Results indicate that p16 and FHIT methylation may be one of the earliest events and an important mechanism for gene silencing in esophageal squamous cell carcinogenesis and may be helpful for screening the candidate molecular markers for early diagnosis of ESCC in high-risk area. Expand
...
1
2
3
4
5
...