Promoter methylation and loss of p16INK4a gene expression in head and neck cancer

@article{Demokan2012PromoterMA,
  title={Promoter methylation and loss of p16INK4a gene expression in head and neck cancer},
  author={Semra Demokan and Alice Y. Chuang and Yusufhan Suoğlu and Murat Ulusan and Zubeyde Yalniz and Joseph A. Califano and Nejat Dalay},
  journal={Head \& Neck},
  year={2012},
  volume={34}
}
Silencing of tumor suppressor genes plays a vital role in head and neck carcinogenesis. In this study we aimed to evaluate aberrant p16INK4a gene promoter methylation in patients with head and neck cancer. 

State of methylation and epigenome studies in some types of head and neck cancer

The main purpose of this study is to review the methylation promoter genes in OSCC and to determine the degree of methylation in these types of tumors, in addition to analyzing the latest studies on the usefulness of these genes as epigenetic markers for early detection and to determined the recurrence of the disease and offer new treatment options.

Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy

Genes regulated by methylation play a modulatory function in HNC susceptibility and it represent a critical therapeutic target to manage patients with advanced disease.

Expression OF p16INK4a Gene in Premalignant and Malignant Lesions of Oral Cavity

The p16 staining was correlated between the control and study groups and p 16 was shown to be increasing expressed in premalignant and less expressed in malignant category and was found to be statistically significant by Fischer's exact test.

Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies

A meta-analysis of 21 published studies identified that aberrant methylation of p16INK4a promoter was found to be significantly associated with HNSCC.

The Association and Clinical Significance of CDKN2A Promoter Methylation in Head and Neck Squamous Cell Carcinoma: a Meta-Analysis

Findings indicate CDKN2A methylation is involved in the carcinogenesis, progression, and metastasis of HNSCC and could be a potential diagnostic and prognostic biomarker for H NSCC.

Promoter DNA Methylation and mRNA Expression Level of p16 Gene in Oral Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics

It appears that P16 status is useful for classifying patients with OSCC and for influencing treatment strategies in accordance with this classification, and targeting the upregulation of p16 could be a promising therapeutic option.

Validation of methylation markers for diagnosis of oral cavity cancer.

Aberrant epigenetic modifications in radiation-resistant head and neck cancers.

This chapter intends to establish an in vitro model for investigating DNA methylation changes in IR-resistant head and neck cancer cells, and Bisulfite pyrosequencing is the main methodology it introduced.

Salivary epigenetic biomarkers in head and neck squamous cell carcinomas.

This review will focus on two commonly aberrant epigenetic alterations: DNA methylation and microRNA expression in HNSCC and their potential clinical utility.

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