Promoter methylation and differential expression of pi-class glutathione S-transferase in endometrial carcinoma.

@article{Chan2005PromoterMA,
  title={Promoter methylation and differential expression of pi-class glutathione S-transferase in endometrial carcinoma.},
  author={Queeny K.Y. Chan and U Y Khoo and Kelvin Yuen-kwong Chan and Hextan Yuen-Sheung Ngan and Shan-shan Li and Pui-Man Chiu and Li-Shan Man and Philip P Ip and Wei-cheng Xue and Annie Nga-Yin Cheung},
  journal={The Journal of molecular diagnostics : JMD},
  year={2005},
  volume={7 1},
  pages={8-16}
}
Pi-class glutathione S-transferase (GSTP1), located on chromosome 11q13, codes for a phase II metabolic enzyme that detoxifies reactive electrophilic intermediates. The protein also interacts with steroid hormones in the human body. The role of GSTP1 in endometrial carcinoma has not been reported. In this study, we aimed at determining the expression of GSTP1 in relation to the epigenetic and genetic changes of the gene in endometrial carcinoma. The GSTP1 protein and mRNA expression was… CONTINUE READING
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